GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7223966 | 1 | rs61360320 | chr17:61800392 | MAP3K3 | chr17:61699775-61773669:+ | 0.26 | 5.37 | 1.26E-7 | Body mass index |
| THCA | cis | rs6137287 | 1 | rs6137287 | chr20:21180259 | PLK1S1 | chr20:21106624-21227256:+ | 0.21 | 5.37 | 1.24E-7 | Height |
| THCA | cis | rs8030605 | 1 | rs61373424 | chr15:56393235 | MNS1 | chr15:56720929-56757335:- | -0.24 | -3.61 | 0.000338 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs8030605 | 1 | rs61373424 | chr15:56393235 | TEX9 | chr15:56657644-56738071:+ | -0.35 | -6.2 | 1.26E-9 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs9546434 | 1 | rs61378129 | chr13:36684353 | SOHLH2 | chr13:36742347-36871992:- | 0.32 | 4.34 | 1.72E-5 | Optic cup area |
| THCA | cis | rs16895812 | 1 | rs61378130 | chr6:42499683 | PRPH2 | chr6:42664334-42690358:- | -0.29 | -3.85 | 0.000135 | Obesity-related traits |
| THCA | cis | rs6138150 | 1 | rs6138139 | chr20:23827431 | CST5 | chr20:23856572-23860380:- | 0.13 | 3.4 | 0.000738 | Response to TNF antagonist treatment |
| THCA | cis | rs6138150 | 1 | rs6138150 | chr20:23847009 | CST5 | chr20:23856572-23860380:- | 0.12 | 3.35 | 0.000872 | Response to TNF antagonist treatment |
| THCA | cis | rs6138150 | 1 | rs6138151 | chr20:23847180 | CST5 | chr20:23856572-23860380:- | 0.13 | 3.43 | 0.000666 | Response to TNF antagonist treatment |
| THCA | cis | rs7267979 | 1 | rs6138572 | chr20:25435934 | ENTPD6 | chr20:25176339-25207360:+ | -0.31 | -6.88 | 1.84E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6138572 | chr20:25435934 | FAM182A | chr20:26035250-26067552:+ | -0.19 | -3.46 | 0.000596 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6138572 | chr20:25435934 | FAM182B | chr20:25744102-25848786:- | 0.25 | 5.08 | 5.38E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6138572 | chr20:25435934 | NINL | chr20:25433338-25566153:- | -0.37 | -7.57 | 1.93E-13 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6138575 | chr20:25438952 | ENTPD6 | chr20:25176339-25207360:+ | -0.31 | -6.88 | 1.84E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6138575 | chr20:25438952 | FAM182A | chr20:26035250-26067552:+ | -0.19 | -3.46 | 0.000596 | Liver enzyme levels (alkaline phosphatase) |